2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. MT-7

MT-7 是一种有效的有丝分裂 (mitotic) 抑制剂。MT-7 具有抗增殖活性。MT-7 诱导细胞周期停滞于 G2/M 期。MT-7 诱导特异性、可逆的有丝分裂停滞并抑制细胞微管聚合。

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MT-7 Chemical Structure

MT-7 Chemical Structure

CAS No. : 946507-08-0

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MT-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MT-7 is a potent mitotic inhibitor. MT-7 shows antiproliferative activity. MT-7 induces cell cycle arrest at G2/M phase. MT-7 induces specific, reversible mitotic arrest and inhibits the polymerization of cellular microtubules[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HeLa IC50
1.8 μM
Compound: 1a (MT-7)
Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay
[PMID: 24360827]
体外研究
(In Vitro)

MT-7 (0-8µM; 72 h) 抑制细胞增殖，对 HeLa、HL60、A549、MDA-MB-468、Lovo、HCT116、SMMC-7721、HO-8910、A375 和 SG7901 细胞的 IC50 值范围为 0.85 μM 至 5.01 μM[1]。
MT-7 (5 μM; 12 h) 诱导细胞周期停滞在 G2/M 期[1]。
MT-7 (5 μM; 1.5、3、6、12 h) 增加 THBS、IL6 和 PHLDA1 的基因表达，降低 COX5B、RPS11 和 CYP26A1 的基因表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MT-7 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HeLa cells
Concentration: 5 μM
Incubation Time: 12 h
Result: Induced cell cycle arrest at G2/M phase and decreased the protein expression of MPM-2, Pi-H3.

RT-PCR[1]

Cell Line: HeLa cells
Concentration: 5 μM
Incubation Time: 1.5, 3, 6, 12 h
Result: Upregulated the gene expression of THBS, IL6 and PHLDA1, doen-regulated the gene expression of COX5B, RPS11 and CYP26A1.
分子量

355.39

Formula

C22H17N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MT-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-7946507-08-0MT7MT 7Microtubule/TubulinHeLa cellsG2/M phaseMPM-2Pi-H3THBSInhibitorinhibitorinhibit

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