2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. myo-Inositol trispyrophosphate hexa-triethylamine

myo-Inositol trispyrophosphate hexa-triethylamine  (Synonyms: ITPP hexa-triethylamine)

目录号: HY-141510A 纯度: ≥98.0%
COA 产品使用指南 技术支持

myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine 是肌醇三磷酸 (ITPP) 盐形式。myo-Inositol trispyrophosphate hexa-triethylamine 是一种膜通透性的血红蛋白变构调节剂。myo-Inositol trispyrophosphate hexa-triethylamine 通过降低血红蛋白对氧的亲和力来增强红细胞氧的释放能力。myo-Inositol trispyrophosphate hexa-triethylamine 可用于心血管疾病和肿瘤的研究。

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myo-Inositol trispyrophosphate hexa-triethylamine Chemical Structure

myo-Inositol trispyrophosphate hexa-triethylamine Chemical Structure

CAS No. : 851086-77-6

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5 mg ￥1800
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10 mg ￥3200
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Other Forms of myo-Inositol trispyrophosphate hexa-triethylamine:

myo-Inositol trispyrophosphate hexa-triethylamine 相关抗体

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查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate hexa-triethylamine is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate hexa-triethylamine enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate hexa-triethylamine can be used in the study of cardiovascular disease and cancer[1][2][3].

体外研究
(In Vitro)

非盐剂量：
myo-Inositol trispyrophosphate (78 mM；1 小时) 在红细胞中能显著降低缺氧诱导的 HIF-1α 表达[1] 。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

myo-Inositol trispyrophosphate hexa-triethylamine 相关抗体:
体内研究
(In Vivo)

非盐剂量：
myo-Inositol trispyrophosphate (1.5 g/kg；腹腔注射；一周两次；4 周) 在心肌梗死大鼠模型中具有保护作用[1]。
myo-Inositol trispyrophosphate (1.5 g/kg；静脉注射；一周一次；11 周) 在胰腺癌大鼠模型中具有抗肿瘤活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (280-320 g) with myocardial infarction[1]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intraperitoneal injection (i.p.); twice a week for 4 weeks
Result: Essentially halted the increase of LV dilation and significantly reduced impairment of LV ejection fraction, while it had no effect on sham-operated rats.
Animal Model: DSL-6A/C1 tumors treated immunocompetent male Lewis rats[2]
Dosage: 1.5 g/kg (Non-salt dose)
Administration: Intravenous injection (i.v.); once a week for 11 weeks
Result: Significantly extended the survival time of rats.
Basically did not cause liver metastasis and primary tumor growth was restricted to 2 cm3.
Restored the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors.
分子量

1213.13

Formula

C6H12O21P6.6C6H15N
CAS 号
性状

油状物

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 125 mg/mL (103.04 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8243 mL 4.1216 mL 8.2431 mL
5 mM 0.1649 mL 0.8243 mL 1.6486 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

myo-Inositol trispyrophosphate hexa-triethylamine 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8243 mL 4.1216 mL 8.2431 mL 20.6078 mL
5 mM 0.1649 mL 0.8243 mL 1.6486 mL 4.1216 mL
10 mM 0.0824 mL 0.4122 mL 0.8243 mL 2.0608 mL
15 mM 0.0550 mL 0.2748 mL 0.5495 mL 1.3739 mL
20 mM 0.0412 mL 0.2061 mL 0.4122 mL 1.0304 mL
25 mM 0.0330 mL 0.1649 mL 0.3297 mL 0.8243 mL
30 mM 0.0275 mL 0.1374 mL 0.2748 mL 0.6869 mL
40 mM 0.0206 mL 0.1030 mL 0.2061 mL 0.5152 mL
50 mM 0.0165 mL 0.0824 mL 0.1649 mL 0.4122 mL
60 mM 0.0137 mL 0.0687 mL 0.1374 mL 0.3435 mL
80 mM 0.0103 mL 0.0515 mL 0.1030 mL 0.2576 mL
100 mM 0.0082 mL 0.0412 mL 0.0824 mL 0.2061 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

myo-Inositol trispyrophosphate hexa-triethylamine851086-77-6ITPP hexa-triethylamineHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHred blood cellsmyocardial infarction modelpancreatic cancer modelInhibitorinhibitorinhibit

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