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  4. myo-Inositol trispyrophosphate hexasodium

myo-Inositol trispyrophosphate hexasodium  (Synonyms: ITPP hexasodium)

目录号: HY-141510 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

myo-Inositol trispyrophosphate (ITPP) hexasodium 是血红蛋白 (haemoglobin) 调节剂，是一种变构效应物，可降低血红蛋白的氧结合亲和力并促进红细胞释放氧。myo-Inositol trispyrophosphatehexasodium 可以逆转缺氧，控制肿瘤生长并改善化疗反应。

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myo-Inositol trispyrophosphate hexasodium Chemical Structure

myo-Inositol trispyrophosphate hexasodium Chemical Structure

CAS No. : 23103-35-7

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规格 价格 是否有货 数量
5 mg ￥1800
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10 mg ￥3200
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Customer Review

myo-Inositol trispyrophosphate hexasodium 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

myo-Inositol trispyrophosphate (ITPP) hexasodium, a modifier of haemoglobin, is an allosteric effector that reduces the oxygen‐binding affinity of haemoglobin and facilitates the release of oxygen by red blood cells. myo-Inositol trispyrophosphate can reverse hypoxia, control tumor growth and improve chemotherapy response[1][2][3].

体外研究
(In Vitro)

myo-Inositol trispyrophosphate hexasodium (10 mmol/L; 2 hours) significantly inhibits OCR in all six cell lines (FSaII, SiHa, MDA‐MB‐231, NT2, 9L‐glioma and rhabdomyosarcoma) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

myo-Inositol trispyrophosphate hexasodium 相关抗体:
体内研究
(In Vivo)

myo-Inositol trispyrophosphate hexasodium (2 g/kg weekly; IP; 7weeks) sustains its significant effect on life prolongation[1].
myo-Inositol trispyrophosphate hexasodium (1.5 g/kg weekly; IV; for 8 weeks) remains metastasis-free on pancreatic carcinomas in immunocompetent male Lewis rats weighing 120-150 g with DSL-6A/C1 cells. myo-Inositol trispyrophosphate hexasodium restores the pO2 pressure in tumors reducing hypoxia-inducible and proangiogenic factors[1].
myo-Inositol trispyrophosphate hexasodium (2 g/kg; once daily for 2 days) shows the most elevated tumour oxygenation at 2 hours in four mouse tumour models (mouse fibrosarcoma FSaII implanted in C3H mice, mouse mammary tumour NT2 in FVb/Nrj mice, human breast cancer MDA‐MB‐231 in NMRI nude mice and human cervix squamous cell carcinoma SiHa in NMRI nude mice) and two rat tumour models (rat 9L‐glioma in Fischer F344 rats and rat rhabdomyosarcoma in WAG/Rij rats)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (20 g) with MiaPaCa-2 or DSL-6A/C1 cells[1]
Dosage: 2 g/kg (weekly)
Administration: IP; weekly; 7weeks
Result: Sustained its significant effect on life prolongation.
分子量

737.88

Formula

C6H6Na6O21P6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 25 mg/mL (33.88 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3552 mL 6.7762 mL 13.5523 mL
5 mM 0.2710 mL 1.3552 mL 2.7105 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (287 KB) HNMR (282 KB) CNMR (191 KB)

产品使用指南 (1538 KB)
参考文献

myo-Inositol trispyrophosphate hexasodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3552 mL 6.7762 mL 13.5523 mL 33.8808 mL
5 mM 0.2710 mL 1.3552 mL 2.7105 mL 6.7762 mL
10 mM 0.1355 mL 0.6776 mL 1.3552 mL 3.3881 mL
15 mM 0.0903 mL 0.4517 mL 0.9035 mL 2.2587 mL
20 mM 0.0678 mL 0.3388 mL 0.6776 mL 1.6940 mL
25 mM 0.0542 mL 0.2710 mL 0.5421 mL 1.3552 mL
30 mM 0.0452 mL 0.2259 mL 0.4517 mL 1.1294 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

myo-Inositol trispyrophosphate hexasodium23103-35-7ITPP hexasodiumOthershaemoglobinoxygen‐bindingredbloodhypoxiachemotherapyInhibitorinhibitorinhibit

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