2. MAPK/ERK Pathway NF-κB Metabolic Enzyme/Protease
  3. MAP3K p38 MAPK JNK NF-κB Endogenous Metabolite
  4. N-Acetylgalactosaminyltransferase 4

N-Acetylgalactosaminyltransferase 4  (Synonyms: GALNT4)

目录号: HY-E70291
产品使用指南

摩尔计算器

N-Acetylgalactosaminyltransferase 4 (GALNT4) 是一种能够抑制 ASK1 激活的糖基转移酶。N-Acetylgalactosaminyltransferase 4 通过直接结合 ASK1，抑制其 N 端二聚化和随后的磷酸化，从而导致下游 JNK/p38 和 NF-κB 信号的强烈失活，进而改善肝脏手术的预后。

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N-Acetylgalactosaminyltransferase 4 Chemical Structure

N-Acetylgalactosaminyltransferase 4 Chemical Structure

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N-Acetylgalactosaminyltransferase 4 相关抗体

Top Publications Citing Use of Products

查看 MAP3K 亚型特异性产品:

查看所有亚型
MAP3K7/TAK1 MAP3K8 ASK2 MAP3K5/ASK1

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Acetylgalactosaminyltransferase 4 (GALNT4) is a glycosyltransferase capable of inhibiting the activation of ASK1. By directly binding to ASK1, N-Acetylgalactosaminyltransferase 4 suppresses its N-terminal dimerization and subsequent phosphorylation, leading to robust inactivation of downstream JNK/p38 and NF-κB signals, and thereby improving the prognosis of liver surgery[1].

IC50 & Target

ASK1

 

中文名称

N-乙酰半乳糖氨基转移酶4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N-Acetylgalactosaminyltransferase 4 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

N-Acetylgalactosaminyltransferase 4GALNT4N-乙酰半乳糖氨基转移酶4GALNT 4GALNT-4MAP3Kp38 MAPKJNKNF-κBEndogenous MetaboliteMAP kinase kinase kinase, MEKK, MAPKKKc-Jun N-terminal kinaseNuclear factor-κBNuclear factor-kappaBliver ischemia-reperfusion injuryInhibitorinhibitorinhibit

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