2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. N-Deschlorobenzoyl indomethacin

N-Deschlorobenzoyl indomethacin (Compound 18) 是吲哚美辛 (HY-14397) 的主要代谢物，其结构中缺少 N-对氯苯甲酰基，因此对 AKR1C2 和 AKR1C3 的抑制活性丧失 (AKR1C2 IC50 =100 μM，AKR1C3 IC50 >100 μM)，且无选择性。

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N-Deschlorobenzoyl indomethacin Chemical Structure

N-Deschlorobenzoyl indomethacin Chemical Structure

CAS No. : 2882-15-7

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N-Deschlorobenzoyl indomethacin 相关抗体

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  • 生物活性

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生物活性

N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the ​N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC50 =100 μM, AKR1C3 IC50 >100 μM), exhibiting no selectivity[1].

分子量

219.24

Formula

C12H13NO3
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

N-Deschlorobenzoyl indomethacin 相关分类

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Keywords:

N-Deschlorobenzoyl indomethacin2882-15-7Drug MetaboliteAKR1C3 inhibitorInhibitorinhibitorinhibit

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