2. Others
  3. Isotope-Labeled Compounds
  4. N-Desmethyl apalutamide-d4

N-Desmethyl apalutamide-d4 

目录号: HY-W754151 纯度: 99.63%
COA 产品使用指南 技术支持

N-Desmethyl apalutamide-d4 是氘代标记的 N-Desmethyl-Apalutamide (HY-135331)。N-Desmethyl Apalutamide 是 Apalutamide 的活性代谢产物，是一种低活性的雄激素受体拮抗剂，其作用力是 Apalutamide 活性的三分之一。N-Desmethyl Apalutamide 的形成主要由 CYP2C8 和 CYP3A4 介导。N-Desmethyl Apalutamide 是中等至强的 CYP3A4 和 CYP2B6 诱导剂，并具有优异的血浆蛋白结合浓度。

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N-Desmethyl apalutamide-d<sub>4</sub> Chemical Structure

N-Desmethyl apalutamide-d4 Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥4500
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N-Desmethyl apalutamide-d4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

N-Desmethyl apalutamide-d4 is the deuterium-labeled N-Desmethyl-Apalutamide (HY-135331). N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration[1][2][3].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Desmethyl apalutamide-d4 相关抗体:
分子量

467.43

Formula

C20H9D4F4N5O2S
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

N-Desmethyl apalutamide-d4 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Desmethyl apalutamide-d4Isotope-Labeled CompoundsMetabolitepharmacologicalCYP2C8CYP3A4CYP2B6plasma-proteinsInhibitorinhibitorinhibit

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