2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. N3-PEG3-vc-PAB-MMAE

N3-PEG3-vc-PAB-MMAE 

目录号: HY-100874 纯度: 98.56%
COA 产品使用指南

摩尔计算器

N3-PEG3-vc-PAB-MMAE 是 drug-linker conjugate for ADC 的一部分，包含抗有丝分裂剂 MMAE (一种 tubulin 抑制剂) 和 3 个单元的 PEG linker。N3-PEG3-vc-PAB-MMAE 具有有效的抗肿瘤活性。N3-PEG3-vc-PAB-MMAE 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。它还可以和含有 DBCO 或 BCN 基团的分子发生环张力驱动的炔-叠氮环加成反应 (SPAAC)。

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N3-PEG3-vc-PAB-MMAE Chemical Structure

N3-PEG3-vc-PAB-MMAE Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2000
In-stock
5 mg ￥5000
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

N3-PEG3-vc-PAB-MMAE 相关抗体

Top Publications Citing Use of Products

查看 Drug-Linker Conjugates for ADC 亚型特异性产品:

查看所有亚型
Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

生物活性

N3-PEG3-vc-PAB-MMAE is a synthesized agent-linker conjugate for ADC that incorporates the MMAE (a tubulin inhibitor ) and 3-unit PEG linker. N3-PEG3-vc-PAB-MMAE shows potent antitumor activity. N3-PEG3-vc-PAB-MMAE is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

Auristatin

 

体外研究
(In Vitro)

Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of Dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N3-PEG3-vc-PAB-MMAE 相关抗体:
分子量

1352.66

Formula

C67H109N13O16
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

纯度 & 产品资料

N3-PEG3-vc-PAB-MMAE 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N3-PEG3-vc-PAB-MMAEDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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产品名称：
N3-PEG3-vc-PAB-MMAE
目录号：
HY-100874
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