2. Metabolic Enzyme/Protease
  3. NAMPT
  4. Nampt-IN-10 trihydrochloride

Nampt-IN-10 trihydrochloride 

目录号: HY-147193A
产品使用指南

摩尔计算器

Nampt-IN-10 trihydrochloride (compound 4) 是磷酸核糖转移酶 (NAMPT) 的抑制剂。Nampt-IN-10 trihydrochloride 对 A2780 和 CORL23 细胞具有活性值，IC50 值分别为 5 和 19 nM。Nampt-IN-10 trihydrochloride 可以作为抗体偶联活性分子 (ADC) 的非限制性有效载荷。

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Nampt-IN-10 trihydrochloride Chemical Structure

Nampt-IN-10 trihydrochloride Chemical Structure

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Nampt-IN-10 trihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC50 values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC)[1].

IC50 & Target

IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)[1]
体外研究
(In Vitro)

Nampt-IN-10 trihydrochloride (0-1 μM; 72 h) 对 A2780, CORL23, c-Kit 和 HER2 的表达细胞株具有细胞毒性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nampt-IN-10 trihydrochloride 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines
Concentration: 0-1 μM
Incubation Time: 72 hours
Result: Showed cytotoxicity to A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC50 values of 5, 19, 2, 0.4 and 1 nM, respectively.
分子量

582.92

Formula

C27H31Cl3FN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nampt-IN-10 trihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nampt-IN-10 trihydrochlorideNAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorA2780CORL23NCI-H526MDA-MB453NCI-N87ADCInhibitorinhibitorinhibit

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目录号：
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