2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation NF-κB
  3. NAMPT Apoptosis Reactive Oxygen Species
  4. Nampt-IN-8

Nampt-IN-8 (Compound 10d) 是一种 NAMPT 抑制剂，IC50 值为 0.183 μM。Nampt-IN-8 也是一种比较好的 NQO1 底物。Nampt-IN-8 诱导凋亡 (apoptosis) 和活性氧 (ROS) 产生。

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Nampt-IN-8 Chemical Structure

Nampt-IN-8 Chemical Structure

CAS No. : 2453183-75-8

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Nampt-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].

IC50 & Target

IC50: 0.183 μM (NAMPT)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
1.15 μM
Compound: 10d
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
11.82 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
124.9 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide, dicumarol, N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminesce
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide, dicumarol, N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminesce
[PMID: 35640078]
A549/TR IC50
14.48 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with NQO1 inhibitor, dicumarol followed by compound addition and measured after for 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with NQO1 inhibitor, dicumarol followed by compound addition and measured after for 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
4.1 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
A549/TR IC50
45.29 μM
Compound: 10d
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
L02 IC50
120.4 μM
Compound: 10d
Antiproliferative activity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
Antiproliferative activity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay
[PMID: 35640078]
体外研究
(In Vitro)

Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC50 of 1.15 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nampt-IN-8 相关抗体:
体内研究
(In Vivo)

Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

573.68

Formula

C36H35N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nampt-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nampt-IN-82453183-75-8NAMPTApoptosisReactive Oxygen SpeciesNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factornon-small-cell lung cancerA549NQO1Inhibitorinhibitorinhibit

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