2. Epigenetics
  3. Epigenetic Reader Domain
  4. NC-III-49-1

NC-III-49-1 是一种有效的二价BET（bivalent bromodomain and extraterminal domain (BET)）抑制剂。NC-III-49-1 显示与 BRD4-1、BRD4-2、BRD4-T、BRDT-1、BRDT-2、BRDT-T 的结合潜力，Kd 值分别为 0.095、0.32、0.29、0.089 、5.5、0.058 nM。NC-III-49-1 显示出抗增殖活性。NC-III-49-1 降低 c-Myc 的表达。

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NC-III-49-1 Chemical Structure

NC-III-49-1 Chemical Structure

CAS No. : 3031654-46-0

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NC-III-49-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc[1].

IC50 & Target[1]

BRD4-1

0.095 nM (Kd)

BRD4-2

0.032 nM (Kd)

BRD4-T

0.29 nM (Kd)

BRDT-1

0.089 nM (Kd)

BRDT-2

5.5 nM (Kd)

BRDT-T

0.058 nM (Kd)

体外研究
(In Vitro)

NC-III-49-1 (0-10 µM; 72 h) shows antiproliferative activity with an IC50 value of 0.69 nM in MM1.S cells[1].
NC-III-49-1 (0-10 µM; 6 h) decreases the expression of c-Myc in a dose dependent manner[1].
. NC-III-49-1 shows inhibition by interact with both KAc sites[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NC-III-49-1 相关抗体:

Cell Viability Assay[1]

Cell Line: MM1.S cells
Concentration: 0-10 µM
Incubation Time: 72 h
Result: Showed subnanomolar growth inhibition with an IC50 value of 0.69 nM in multiple myeloma MM1.S cells.

Western Blot Analysis[1]

Cell Line: MM1.S cells
Concentration: 0-10 µM
Incubation Time: 6 h
Result: Decreased the expression of c-Myc in a dose dependent manner.
体内研究
(In Vivo)

NC-III-49-1 shows metabolic stability in human and mouse liver microsomes with an T1/2 values of <2.3, <2.3 min, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

875.02

Formula

C44H50N4O11S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NC-III-49-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NC-III-49-13031654-46-0Epigenetic Reader Domainantiproliferativec-MycMM1.S cellsmetabolic stabilityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-150683
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