2. Autophagy JAK/STAT Signaling
  3. Autophagy Pim
  4. NDBM

NDBM 是一种肿瘤特异性的与 Pim-1 kinase 结合的探针，可以释放强荧光，产生细胞毒性，从而达到筛选和杀伤细胞的作用。NDBM 能特异性靶向溶酶体，对 pH 值灵敏。NDBM 可用于追踪自噬 (autophagy) 和外界刺激条件下细胞内环境 pH 值的变化。

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NDBM Chemical Structure

NDBM Chemical Structure

CAS No. : 2958641-42-2

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NDBM 相关抗体

Top Publications Citing Use of Products

查看 Pim 亚型特异性产品:

查看所有亚型
PIM1 PIM2 PIM3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation[1].

IC50 & Target

Pim-1[1]
体内研究
(In Vivo)

NDBM 在正常细胞 (HUVEC、RAW 264.7细胞系) 中的荧光强度低于肿瘤细胞 (MGC-803、HepG2 和Hela 细胞系) [1]。
NDBM (2.5、5、10和20 μM, 18 h) 降低肿瘤细胞 (MGC-803、HepG 2和 Hela) 的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

679.56

Formula

C33H35BrN4O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NDBM 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDBM2958641-42-2AutophagyPimPim kinasesPim-1 kinaseAnticancerMGC-803HepG2HelaInhibitorinhibitorinhibit

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