2. Apoptosis
  3. Apoptosis
  4. Nemorosone

Nemorosone 是 Clusia rosea 树脂的主要成分。Nemorosone 对癌细胞有抗增殖作用。Nemorosone 诱导 HT-29 和 LoVo 细胞凋亡 (apoptosis)。

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Nemorosone Chemical Structure

Nemorosone Chemical Structure

CAS No. : 351416-47-2

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规格 价格 是否有货 数量
1 mg ￥927
3 - 4 周
5 mg   询价  
10 mg   询价  

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Nemorosone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

IC50 & Target

apoptosis[1]
体外研究
(In Vitro)

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nemorosone 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HT-29 and LoVo cells
Concentration: 0-50 μM
Incubation Time: 24-72 h
Result: Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Increased the percentage of G0/G1 phase cells.

Apoptosis Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Induced apoptosis in both cell lines.
体内研究
(In Vivo)

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2]
Dosage: 50 mg/kg
Administration: Daily i.p. injections for 28 days
Result: Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2].
分子量

502.68

Formula

C33H42O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nemorosone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemorosone351416-47-2ApoptosisCancerHT-29 cellsLoVo cellsMIA-PaCa-2 cellsantiproliferativeInhibitorinhibitorinhibit

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