Neocarzinostatin  (Synonyms: Zinostatin; Vinostatin)

Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment ^[1][2].

EpCAM 适体偶联的 eocarzinostatin (NCS) 显示出对 EpCAM 阳性细胞的特异性。缀合物对癌细胞的影响令人印象深刻，因为缀合物会阻止细胞周期并促进细胞凋亡和坏死。高水平的 PARP 表达证实了 DNA 在缀合物处理后断裂。与 EpCAM 结合的 NCS 可以靶向癌细胞而保留正常细胞^[3]。
Neocarzinostatin (72 小时) 对 C6 细胞和 U87MG 的 IC₅₀ 值细胞分别为493.64 nM、462.96 nM^[4]。
在不同组织来源的人肿瘤细胞系中对 Neocarzinostatin 的敏感性与Bcl-2相对含量的乘积成正比和 caspase-3^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

9014-02-2

液体

Colorless to light yellow

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Athyala PK, et al. Probing the biophysical interaction between Neocarzinostatin toxin and EpCAM RNA aptamer. Biochem Biophys Res Commun. 2016 Jan 8;469(2):257-62.  [Content Brief]

  [2]. Allen Taylor, et al. Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia. Oncogene (2002) 21, 4363- 4373.

  [3]. Athyala PK, et al. Neocarzinostatin, Aptamer Conjugates for Targeting EpCAM-positive Tumor Cells. Anticancer Res. 2017 Jul;37(7):3615-3629.  [Content Brief]

  [4]. Tianqin G, et al. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biol Pharm Bull. 2016 Oct 1;39(10):1623-1630.  [Content Brief]

  [5]. Rogers D, et al. Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy.  [Content Brief]