2. Apoptosis
  3. Apoptosis
  4. Neoechinulin A

Neoechinulin A 是一种异戊烯基吲哚生物碱，具有清除、神经营养因子样和抗凋亡活性。Neoechinulin A 诱导小鼠记忆改善和抗抑郁样作用。

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Neoechinulin A Chemical Structure

Neoechinulin A Chemical Structure

CAS No. : 51551-29-2

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Neoechinulin A 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Huh7.5.1 CC50
> 20 μM
Compound: 7
Cytotoxicity against human Huh-7.5.1 cells assessed as reduction in cell viability measured at 72 hrs by MTT assay
Cytotoxicity against human Huh-7.5.1 cells assessed as reduction in cell viability measured at 72 hrs by MTT assay
[PMID: 34967639]
MDCK CC50
> 200 μM
Compound: 17
Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
Cytotoxicity against MDCK cells assessed as cell growth after 40 hrs by CellTiter-Glo assay
[PMID: 25681711]
Vero C1008 CC50
> 100 μM
Compound: 7
Cytotoxicity against African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based confocal microscopic analysis
Cytotoxicity against African green monkey Vero E6 cells expressing TMPRSS2 assessed as reduction in cell viability incubated for 24 hrs by DAPI staining based confocal microscopic analysis
[PMID: 34967639]
体外研究
(In Vitro)

Neoechinulin A (RAW264.7 macrophages; 3 hours; cells then stimulated with LPS (1 μg/mL) for 18 hours) suppresses PGE2, TNF-α, and IL-1β production in a dose-dependent manner[2].
Neoechinulin A can suppress the production of pro-inflammatory mediators and cytokines including NO, PGE2, TNF-α, and IL-1β. Further, it reduced the expression of iNOS and COX-2 in LPS-stimulated RAW264.7 macrophages by inhibiting the NF-κB and p38 MAPK signaling pathways[2].
Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neoechinulin A 相关抗体:
体内研究
(In Vivo)

In the Y-maze test, the intracerebroventicular (i.c.v.) administration of LPS (10 μg/mouse) significantly decreased spontaneous alternation behavior, which was prevented by the prior administration of neoechinulin A (300ng/mouse, i.c.v.)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

323.39

Formula

C19H21N3O2
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

fungus Aspergillus sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥98.0%

COA (273 KB)

产品使用指南 (1538 KB)
参考文献

Neoechinulin A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neoechinulin A51551-29-2Apoptosisalkaloidmemoryimprovementsantidepressantinflammationpro-inflammatoryRAW264.7macrophagesInhibitorinhibitorinhibit

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