2. Metabolic Enzyme/Protease
  3. Elastase
  4. Neutrophil elastase inhibitor 3

Neutrophil elastase inhibitor 3 (compound 13)，是一种苯并噁唑酮类似物，对超氧阴离子生成具有影响，并且表现出对中性粒细胞弹性蛋白酶 (NE) 的抑制作用，其对 NE 释放的 IC50 值为 80.8 nM。

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Neutrophil elastase inhibitor 3 Chemical Structure

Neutrophil elastase inhibitor 3 Chemical Structure

CAS No. : 1234707-32-4

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Neutrophil elastase inhibitor 3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neutrophil elastase inhibitor 3 (compound 13), a benzoxazinone analog, shows effects on superoxide anion generation and exhibits as a neutrophil elastase (NE) inhibitor, with an IC50 of 80.8 nM for NE release[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Neutrophil IC50
25000 nM
Compound: 13
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP-induced superoxide anion generation treated 5 mins before FMLP challenge measured after 10 mins by spectrophotometer analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP-induced superoxide anion generation treated 5 mins before FMLP challenge measured after 10 mins by spectrophotometer analysis
[PMID: 20417587]
Neutrophil IC50
80.8 nM
Compound: 13
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP-induced neutrophil elastase release treated 5 mins before FMLP challenge measured after 10 mins
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP-induced neutrophil elastase release treated 5 mins before FMLP challenge measured after 10 mins
[PMID: 20417587]
体内研究
(In Vivo)

Neutrophil elastase inhibitor 3 (compound 13, 1 mg/kg of body weight, 静脉给药) 显著减轻了大鼠创伤性失血性休克后肺部髓过氧化物酶 (MPO) 活性和水肿的增加。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

336.57

Formula

C14H7BrClNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

  • 方案 一

    Neutrophil elastase inhibitor 3 (compound 13) is dissolved in 10% DMSO[1].

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Neutrophil elastase inhibitor 3 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neutrophil elastase inhibitor 31234707-32-4Neutrophil elastase inhibitor3Neutrophil elastase inhibitor-3ElastaseNeutrophil elastasebenzoxazinonemyeloperoxidaseMPOInhibitorinhibitorinhibit

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产品名称：
Neutrophil elastase inhibitor 3
目录号：
HY-132132
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