2. Immunology/Inflammation
  3. Nuclear Factor of activated T Cells (NFAT)
  4. NFATc1-IN-1

NFATc1-IN-1 (compound A04) 一种是 RANKL- 诱导的破骨细胞 (osteoclast) 形成的有效抑制剂，其 IC50 为 1.57 μM。NFATc1-IN-1 通过降低 RANKL 诱导的 NFATc1 核转位，显示抗破骨细胞 (anti-osteoclastogenic) 作用。NFATc1-IN-1 可用于破骨疾病的研究。

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NFATc1-IN-1 Chemical Structure

NFATc1-IN-1 Chemical Structure

CAS No. : 1912422-56-0

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Customer Review

NFATc1-IN-1 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RAW264.7 IC50
1.57 μM
Compound: A04
Inhibition of RANKL-induced osteoclast differentiation in mouse RAW264.7 cells assessed as reduction in TRAP-positive multinucleated cells level incubated with compound in presence of RANKL for 4 days by TRAP staining based light microscopic analysis rela
Inhibition of RANKL-induced osteoclast differentiation in mouse RAW264.7 cells assessed as reduction in TRAP-positive multinucleated cells level incubated with compound in presence of RANKL for 4 days by TRAP staining based light microscopic analysis rela
[PMID: 27089213]
RAW264.7 CC50
7.4 μM
Compound: A04
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 27089213]
体外研究
(In Vitro)

NFATc1-IN-1 (compound A04) (0-2.5 μM, 4 days) exhibits potent inhibitory activities on osteoclast formation and function, which eventually translates into decreased bone resorption[1].
NFATc1-IN-1 (1.5-2.5 μM, 24 h) blocks NFATc1 nuclear translocation and decreases the level of NFATc1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NFATc1-IN-1 相关抗体:

Cell Viability Assay[1]

Cell Line: Osteoclast precursor RAW 264.7 cells
Concentration: 0, 0.5, 1.0, 1.5, 2.0 and 2.5 μM
Incubation Time: 4 days
Result: Markedly reduced the number and size of red TRAP-positive multinucleated osteoclasts at concentrations of 1.5, 2.0, and 2.5 μM. Significantly inhibited formation of osteoclasts in a dose-dependent manner (at 1.5, 2.0 and 2.5 μM), while showing no cytotoxic effects towards osteoclast precursor cells at concentrations of as high as 2.5 μM.

Immunofluorescence[1]

Cell Line: RAW264.7 cells
Concentration: 1.5 or 2.5 μM
Incubation Time: 24 h
Result: Blocked NFATc1 nuclear translocation and decreased the level of NFATc1.
分子量

375.11

Formula

C13H8F2INO2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (333.24 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6659 mL 13.3294 mL 26.6588 mL
5 mM 0.5332 mL 2.6659 mL 5.3318 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

NFATc1-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6659 mL 13.3294 mL 26.6588 mL 66.6471 mL
5 mM 0.5332 mL 2.6659 mL 5.3318 mL 13.3294 mL
10 mM 0.2666 mL 1.3329 mL 2.6659 mL 6.6647 mL
15 mM 0.1777 mL 0.8886 mL 1.7773 mL 4.4431 mL
20 mM 0.1333 mL 0.6665 mL 1.3329 mL 3.3324 mL
25 mM 0.1066 mL 0.5332 mL 1.0664 mL 2.6659 mL
30 mM 0.0889 mL 0.4443 mL 0.8886 mL 2.2216 mL
40 mM 0.0666 mL 0.3332 mL 0.6665 mL 1.6662 mL
50 mM 0.0533 mL 0.2666 mL 0.5332 mL 1.3329 mL
60 mM 0.0444 mL 0.2222 mL 0.4443 mL 1.1108 mL
80 mM 0.0333 mL 0.1666 mL 0.3332 mL 0.8331 mL
100 mM 0.0267 mL 0.1333 mL 0.2666 mL 0.6665 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NFATc1-IN-11912422-56-0Nuclear Factor of activated T Cells (NFAT)RAW 264.7 cellsanti-osteoclastogeneticosteoclastogenesissalicylanilide derivativeOsteoclastNFATc1anti-resorptiveRANKLInhibitorinhibitorinhibit

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