2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. NH-bis-PEG2

NH-bis-PEG2 是一种不可裂解 (non-cleavable) 的 2 单元 PEG 的 ADC linker，用于抗体活性分子偶联物 (ADCs) 的合成。NH-bis-PEG2 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

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NH-bis-PEG2 Chemical Structure

NH-bis-PEG2 Chemical Structure

CAS No. : 54384-47-3

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50 mg ￥750
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100 mg ￥1200
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NH-bis-PEG2 相关抗体

Top Publications Citing Use of Products

查看 ADC Linker 亚型特异性产品:

查看所有亚型
Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

查看 PROTAC Linkers 亚型特异性产品:

查看所有亚型
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NH-bis-PEG2 is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target

Non-cleavable Linker

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NH-bis-PEG2 相关抗体:
分子量

193.24

Formula

C8H19NO4
CAS 号
性状

液体（密度：1.090±0.06 g/cm3）

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

NH-bis-PEG2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH-bis-PEG254384-47-3ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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产品名称：
NH-bis-PEG2
目录号：
HY-130328
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