2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. NH2-MPAA-NODA

NH2-MPAA-NODA 是一种基于硝基的可光裂解的 linker，它有一个 NODA 修饰单元和一个 MPAA 主链。NH2-MPAA-NODA 可以通过标记 18F-氟化物来用作放射性标签。

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NH2-MPAA-NODA Chemical Structure

NH2-MPAA-NODA Chemical Structure

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Customer Review

NH2-MPAA-NODA 相关抗体

Top Publications Citing Use of Products

查看 ADC Linker 亚型特异性产品:

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  • 生物活性

  • 纯度 & 产品资料

生物活性

NH2-MPAA-NODA is a nitroveratryl-based photocleavable linker, it has a NODA motif and a methyl phenyl acetic acid (MPAA) backbone[1]. NH2-MPAA-NODA can be used as a radiolabel by labeling with 18F-fluoride.

IC50 & Target

IC50: Nitroveratryl-based photocleavable linker
体外研究
(In Vitro)

NH2-MPAA-NODA contains the 1,4,7-triazacyclononane-1,4-diacetate (NODA) motif with a methyl phenyl acetic acid (MPAA) backbone, and it has enough ability to form stable Al18F-chelates. The organ of luoroaluminates are easily accessible from the reaction of 1 and AlF3.
NH2-MPAA-NODA can be conjugated to some inhibitors/antagonists labeled with 18F for PET imaging of targeting tumors. It also can be used as a radiolabel of peptides[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NH2-MPAA-NODA 相关抗体:
分子量

435.52

Formula

C21H33N5O5
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥97.0%

COA (260 KB)

产品使用指南 (1538 KB)

NH2-MPAA-NODA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NH2-MPAA-NODAADC LinkerAntibody-drug conjugates linkerCleavable,linkertumorradiolabelpeptidefluorideInhibitorinhibitorinhibit

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产品名称：
NH2-MPAA-NODA
目录号：
HY-135859
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