2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. Niacin hydrochloride

Niacin hydrochloride  (Synonyms: B3维生素; Nicotinic acid hydrochloride; Vitamin B3 hydrochloride)

目录号: HY-B0143A
产品使用指南

摩尔计算器

Niacin (Vitamin B3; Nicotinic acid) hydrochloride 是一种具有口服活性的 B3 维生素 (B3 vitamin)，是人类必需的营养物质。Niacin hydrochloride 在能量代谢、细胞信号级联调节基因表达和细胞凋亡 (apoptosis) 中起关键作用，也可用于心血管疾病的研究。

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Niacin hydrochloride Chemical Structure

Niacin hydrochloride Chemical Structure

CAS No. : 636-79-3

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Niacin hydrochloride 的其他形式现货产品:

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Other Forms of Niacin hydrochloride:

Niacin hydrochloride 相关抗体

Top Publications Citing Use of Products

    Niacin hydrochloride purchased from MCE. Usage Cited in: Glia. 2018 Feb;66(2):256-278.  [Abstract]

    Representative images and quantitative analysis showing the effects of Niacin (1 mM, 10 min) and MK-6892 (10 lM, 10 min) on Akt phosphorylation levels in primary cultured microglia.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体外研究
    (In Vitro)

    Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1].
    Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Niacin hydrochloride 相关抗体:

    RT-PCR[1]

    Cell Line: Cumulus cells and oocytes of prepubertal gilts
    Concentration: 600 μM
    Incubation Time: 42 hours
    Result: Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX.

    Cell Proliferation Assay[2]

    Cell Line: Rat ascites hepatoma cell line of AH109A
    Concentration: 0-40 μM
    Incubation Time: 24 hours
    Result: Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.
    体内研究
    (In Vivo)

    Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice[3]
    Dosage: 3-300 mg/kg
    Administration: Subcutaneous injection; once
    Result: Induced vasodilation in a dose-dependent manner.
    Clinical Trial
    分子量

    159.57

    Formula

    C6H6ClNO2
    CAS 号
    中文名称

    B3维生素
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Niacin hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Niacin636-79-3Nicotinic acidVitamin B3B3维生素Vitamin B 3Vitamin B-3Endogenous MetaboliteApoptosisapoptosiscardiovascular diseasescancerInhibitorinhibitorinhibit

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