2. Membrane Transporter/Ion Channel Immunology/Inflammation Anti-infection Apoptosis Stem Cell/Wnt
  3. Potassium Channel NOD-like Receptor (NLR) Bacterial Antibiotic Pyroptosis Wnt β-catenin
  4. Nigericin (sodium salt) (Standard)

Nigericin (sodium salt) (Standard)  (Synonyms: 尼日利亚菌素钠盐 (Standard))

目录号: HY-100381R 纯度: ≥98%
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摩尔计算器

Nigericin (sodium salt) (Standard)是 Nigericin (sodium salt) 的分析标准品。本产品用于研究及分析应用。Nigericin sodium salt 是一种抗生素 (antibiotic)，源自 Streptomyces hygroscopicus，充当 K+/H+ 离子载体 (K+/H+ ionophore)，促进 K+/H+ 跨线粒体膜交换。Nigericin sodium salt 是 NLRP3 的激活剂。Nigericin sodium salt 通过降低细胞内 pH (pHi) 和 Wnt/β-catenin 通路信号而显示出良好的抗癌活性。Nigericin sodium salt 在 TNBC 中通过 caspase 1/GSDMD 途径诱导细胞焦亡 (pyroptosis)。

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Nigericin (sodium salt) (Standard) Chemical Structure

Nigericin (sodium salt) (Standard) Chemical Structure

CAS No. : 28643-80-3

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生物活性

Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt). This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC.

分子量

746.94

Formula

C40H67NaO11
CAS 号
中文名称

尼日利亚菌素钠盐 (Standard)；尼日利亚菌素钠 (Standard)
结构分类
初始来源
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Nigericin (sodium salt) (Standard) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nigericin (sodium salt) (Standard)28643-80-3尼日利亚菌素钠盐 (Standard)尼日利亚菌素钠 (Standard)Potassium ChannelNOD-like Receptor (NLR)BacterialAntibioticPyroptosisWntβ-cateninKcsABeta cateninInhibitorinhibitorinhibit

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