2. Anti-infection
  3. RSV
  4. Nirsevimab

Nirsevimab  (Synonyms: 尼塞韦单抗; MEDI8897)

目录号: HY-P99756 纯度: 98.00%
COA

摩尔计算器

Nirsevimab (MEDI8897) 是一种重组人呼吸道合胞病毒 (RSV) 单克隆抗体。Nirsevimab 对 RSV A 和 RSV B 病毒具有中和活性，IC50 值分别为 5.42 ng/mL 和 9.71 ng/mL。Nirsevimab 可以用于呼吸道感染的研究。

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CAS No. : 1989556-22-0

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规格 价格 是否有货 数量
1 mg ￥4000
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Nirsevimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections[1][2].
同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

IC50: 5.42 ng/mL, 9.71 ng/mL (RSV A, RSV B)[1].
体外研究
(In Vitro)

Nirsevimab 可以直接中和 RSV 病毒并具有片段可结晶 (Fc) 介导的效应器功能，从而预防呼吸道感染[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nirsevimab 相关抗体:
体内研究
(In Vivo)

Nirsevimab (10-10000 μg/kg; 肌肉注射) 在 RSV 病毒感染前预先给药可以抑制小鼠呼吸道粘膜的抗体反应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3-week-old female BALB/c mice[2].
Dosage: 10 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Intramuscular injection (i.m.); administer medication 24 hours prior to RSV virus exposure
Result: Inhibited the secretion of sIgA, mucosal IgA, and mucosal IgG in the offspring subsequent to the initial RSV infection.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

尼塞韦单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献

Nirsevimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nirsevimab1989556-22-0MEDI8897尼塞韦单抗MEDI 8897MEDI-8897RSVRespiratory syncytial virusantibodyrespiratory tract infectionInhibitorinhibitorinhibit

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