2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NLRP3-IN-45

NLRP3-IN-45 (D6) 是 NLRP3 炎症小体活化的抑制剂，抑制 IL-1β 的活性 (IC50=41.79 nM)。NLRP3-IN-45 通过抑制 NLRP3 炎症小体的激活发挥作用而不影响 NLRP3 炎症小体激活的起始阶段。NLRP3-IN-45 在 LPS 诱导的急性肺损伤 (ALI) 小鼠模型中特异性抑制 NLRP3 炎症小体的激活。

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NLRP3-IN-45 Chemical Structure

NLRP3-IN-45 Chemical Structure

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NLRP3-IN-45 相关抗体

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查看 NOD-like Receptor (NLR) 亚型特异性产品:

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NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NLRP3-IN-45 (D6) is an inhibitor of NLRP3 inflammasome activation, inhibiting the activity of IL-1β (IC50=41.79 nM). NLRP3-IN-45 exerts its effects by inhibiting the activation of NLRP3 inflammasome without affecting the initial stage of NLRP3 inflammasome activation. NLRP3-IN-45 specifically inhibits the activation of NLRP3 inflammasome in the LPS-induced acute lung injury (ALI) mouse model[1].

IC50 & Target

NLRP3 inflammasome

 

体外研究
(In Vitro)

NLRP3-IN-45 (0.2-5 μM，1 h) 在 BMDMs 细胞中可抑制 NLRP3 炎症小体的激活，且不影响 AIM2 和 NLRC4 炎症小体的激活[1]。
NLRP3-IN-45 (0.2-5 μM，1 h) 不影响 NLRP3 炎症小体激活的启动阶段[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NLRP3-IN-45 相关抗体:

Western Blot Analysis[1]

Cell Line: a NLRP3 inflammasome model in BMDMs cells; a AIM2 and NLRC4 inflammasome model in BMDMs cells
Concentration: 0.2, 1, 5 μM
Incubation Time: 1 h
Result: Inhibited the secretion of IL-1β and Caspase-1 mediated by NLRP3 inflammasome in a concentration-dependent manner, and at a concentration of 1 μM, it was beneficial to reduce the level of IL-1β induced by various stimuli[1].
Had no significant effect on the expression of TNF-α, Pro-IL-1β, Pro-caspase-1, NLRP3 and ASC proteins[1].
Had no effect on the secretion of IL-1β and Caspase-1 mediated by AIM2 and NLRC4 inflammasome[1].
体内研究
(In Vivo)

NLRP3-IN-45 (0.1-10 mg/kg，一天一次，3天) 在急性肺损伤小鼠模型中抑制 NLRP3 炎性体的激活，对急性肺损伤有保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced ALI mice[1]
Dosage: 0.1, 1, 10 mg/kg; once a day; 3 days
Administration: Intraperitoneal injection (i.p.)
Result: Made the mice appear more active and the mice lost weight[1].
Reduced serum levels of IL-6, TNF-α, IL-1β, and BALF in a dose-dependent manner[1].
Weakened lung tissue lesions and significantly inhibited the secretion of IL-1β and Caspase-1 mediated by NLRP3 inflammasome activation[1].
分子量

483.53

Formula

C27H30FNO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NLRP3-IN-45 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-45NOD-like Receptor (NLR)A NLRP3 inflammasome model in mouseAcute lung injuryInflammasome activationInhibitorinhibitorinhibit

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