2. Apoptosis Immunology/Inflammation
  3. Pyroptosis NOD-like Receptor (NLR)
  4. NLRP3-IN-55

NLRP3-IN-55 (Compound 19) 是一种有效的 NLRP3 抑制剂（IC50 = 0.34 μM）。NLRP3-IN-55 直接靶向 NLRP3 蛋白（KD = 0.45 μM），阻断 NLRP3 炎症小体的组装和激活，从而产生抗炎作用并抑制细胞焦亡 (pyroptosis)。

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NLRP3-IN-55 Chemical Structure

NLRP3-IN-55 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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NLRP3-IN-55 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

查看所有亚型
NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NLRP3-IN-55 (Compound 19) is a potent NLRP3 inhibitor (IC50 = 0.34 μM). NLRP3-IN-55 directly targets the NLRP3 protein (KD = 0.45 μM), blocking the assembly and activation of the NLRP3 inflammasome, leading to anti-inflammatory effects and inhibition of cellular pyroptosis[1].

IC50 & Target

NLRP3

0.34 μM (IC50)

NLRP3

0.45 μM (Kd)

分子量

561.04

Formula

C32H30ClFN2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NLRP3-IN-55 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3-IN-55PyroptosisNOD-like Receptor (NLR)NLRP3 inflammasomeanti-inflammatorypyroptosisInhibitorinhibitorinhibit

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目录号：
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