1. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  2. Microtubule/Tubulin Apoptosis
  3. NMK-TD-100

NMK-TD-100 是微管 (microtubule) 调节剂。NMK-TD-100 与微管蛋白结合,抑制微管蛋白聚合 (IC50 为 17.5 µM),抑制有丝分裂,降低线粒体膜电位 (MMP)。NMK-TD-100 抑制 HeLa 细胞增殖 (IC50 为 1.42 µM),将细胞周期停滞在 G2/M 期,诱导 HeLa 细胞凋亡 (apoptosis)。

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NMK-TD-100 Chemical Structure

NMK-TD-100 Chemical Structure

CAS No. : 1252802-38-2

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  • 生物活性

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生物活性

NMK-TD-100 is a modulator for microtubule. NMK-TD-100 binds to tubulin, inhibits the tubulin polymerization with an IC50 of 17.5 µM, inhibits mitosis, and decreases mitochondrial membrane potential (MMP). NMK-TD-100 inhibits the proliferation of HeLa with an IC50 of 1.42 µM, arrests cell cycle at G2/M phase, induces apoptosis in HeLa[1].

分子量

367.42

Formula

C19H17N3O3S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

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NMK-TD-100
目录号:
HY-120490
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