1. Apoptosis Immunology/Inflammation
  2. RIP kinase NOD-like Receptor (NLR)
  3. NOD1/2-IN-1

NOD1/2-IN-1 (Compound 18) 是一种强效 RIPK2 抑制剂,通过 ADP-Glo 检测得到的 IC50 值为 1.4 nM。NOD1/2-IN-1 通过抑制 NOD1/NOD2 通路 (对 NOD1NOD2 IC50 分别为 18 和 170 nM),来阻断促炎性细胞因子的产生,从而减少炎症反应。NOD1/2-IN-1 可用于结肠炎领域研究。

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NOD1/2-IN-1 Chemical Structure

NOD1/2-IN-1 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor with an IC50 value of 1.4 nM, as determined by the ADP-Glo assay. NOD1/2-IN-1 blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathways, with IC50 values of 18 nM and 170 nM for NOD1 and NOD2, respectively, thereby reducing inflammatory responses. NOD1/2-IN-1 can be used in studies related to colitis[1].

IC50 & Target

NOD1

18 nM (IC50)

NOD2

170 nM (IC50)

分子量

423.53

Formula

C22H25N5O2S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
NOD1/2-IN-1
目录号:
HY-168024
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