2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. JAK Apoptosis
  4. NSC114792

NSC114792 是一种选择性 JAK3 抑制剂。NSC114792 可诱导细胞凋亡 (apoptosis)。NSC114792 可降低 p-JAK3 和 p-STAT5 的蛋白表达。

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NSC114792 Chemical Structure

NSC114792 Chemical Structure

CAS No. : 17392-79-9

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NSC114792 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

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JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5[1].

IC50 & Target[1]

JAK3

 

体外研究
(In Vitro)

NSC114792 (0, 5, 10, 20 µM; 24, 48, 72 h) 以时间和剂量依赖性方式抑制 BaF3-JAK3V674A 和 BKO84 细胞活力[1]。
NSC114792 (0, 5, 10, 20 µM) 以剂量依赖性方式降低 p-JAK3 和 p-STAT5 的蛋白表达[1]。
NSC114792 (0, 5, 10, 20 µM; 72 h) 以剂量依赖性方式诱导 L540 细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC114792 相关抗体:

Cell Viability Assay[1]

Cell Line: L540, HDLM-2, MDA-MB-468, DU145 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 0, 24, 48, 72 h
Result: Inhibited cell viability in a time and dose-dependent manner.

Western Blot Analysis[1]

Cell Line: BKO84 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time:
Result: Decreased the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: L540 cells
Concentration: 0, 10, 20 µM
Incubation Time: 72 h
Result: Induced apoptosis and increased the expression of cleaved PARP and cleaved Capase-3, decreased the protein expression of Bcl-2, Bcl-Xl, Mcl-1, Survivin in a dose-dependent manner.
分子量

464.62

Formula

C26H32N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC114792 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC11479217392-79-9NSC 114792NSC-114792JAKApoptosisJanus kinaseBKO84 cellsL540 cellsapoptosisp-JAK3p-STAT5Inhibitorinhibitorinhibit

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