2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. NSC624206

NSC624206 是一种泛素 E1 (UBA1) 抑制剂，其 IC50 值为 ~9 μM。NSC624206 特异性地阻断泛素-硫代酯的形成，但对泛素腺化无影响。

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NSC624206 Chemical Structure

NSC624206 Chemical Structure

CAS No. : 13116-77-3

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规格 价格 是否有货 数量
1 mg ￥855
3 - 4 周
5 mg ￥3240
3 - 4 周
10 mg ￥5508
3 - 4 周
50 mg   询价  
100 mg   询价  

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NSC624206 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].

IC50 & Target

IC50: ~9 μM (ubiquitin E1)[1]
体外研究
(In Vitro)

NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line[1].
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC50 of 13 μM[1].
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC624206 相关抗体:

Western Blot Analysis[1]

Cell Line: Kip16 cells
Concentration: 10 nM-10 μM
Incubation Time: 24 hours
Result: Induced accumulation of p27.
分子量

410.51

Formula

C19H33Cl2NS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC624206 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC62420613116-77-3NSC 624206NSC-624206E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseubiquitinE1p27kip1proteolysisubiquitin-thioesterInhibitorinhibitorinhibit

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