2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. Nurr1 agonist 9

Nurr1 agonist 9 (Compound 36) 是 Nurr1 的激动剂，EC50 为 0.090 µM，Kd 为 0.17 µM。Nurr1 agonist 9 可激活 Nurr1 同型二聚体 (NurRE，EC50=0.094 µM) 和 Nurr1-RXR 异型二聚体 (DR5，EC50=0.165 µM)。Nurr1 agonist 9 可诱导类器官帕金森病模型中 Nurr1 调节的酪氨酸羟化酶 (TH) 的表达。 Nurr1 agonist 9 可透过人脑内皮细胞屏障。

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Nurr1 agonist 9 Chemical Structure

Nurr1 agonist 9 Chemical Structure

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Nurr1 agonist 9 相关抗体

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查看 Nuclear Hormone Receptor 4A/NR4A 亚型特异性产品:

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Nurr1/NR4A2 Nur77/NR4A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM). Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable[1].

IC50 & Target

Nurr1/NR4A2

0.09 μM (EC50)

Nurr1/NR4A2

0.17 μM (Ki)

分子量

394.85

Formula

C21H19ClN4O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nurr1 agonist 9 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nurr1 agonist 9Nuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like ReceptorT98G astrocytesHEK293TParkinson’s DiseaseInhibitorinhibitorinhibit

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