2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. O-Desmethylcarvedilol

O-Desmethylcarvedilol  (Synonyms: O-去甲卡维地洛; Desmethylcarvedilol; BM-14242)

目录号: HY-Z7733
产品使用指南 技术支持

O-Desmethylcarvedilol (Desmethylcarvedilol) 是非选择性 β-肾上腺素受体 (β-AR) 拮抗剂 Carvedilol (HY-B0006) 的活性代谢物。O-Desmethylcarvedilol 可抑制表达瑞安诺丁受体 2 (RyR2) R4496C (RyR2R4496C) 突变的 HEK293 细胞中储存超载诱导的钙释放 (IC50 = 7.62 µM)。 O-Desmethylcarvedilol 可减缓清醒兔子的心率增加并防止 Isoproterenol（HY-B0468）引起的舒张压下降（ED50s = 32 和 5 µg/kg）。

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O-Desmethylcarvedilol Chemical Structure

O-Desmethylcarvedilol Chemical Structure

CAS No. : 72956-44-6

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O-Desmethylcarvedilol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively)[1][2].

分子量

392.45

Formula

C23H24N2O4
CAS 号
中文名称

O-去甲卡维地洛
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

O-Desmethylcarvedilol 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

O-Desmethylcarvedilol72956-44-6Desmethylcarvedilol BM-14242O-去甲卡维地洛BM14242BM 14242BM-14242Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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