2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. OHM1

OHM1 是 HIF1α CTAD 的类似物，抑制其与 p300/CBP 的结合。OHM1 靶向 CH1 结构域，亲和力为 0.53 μM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

OHM1 Chemical Structure

OHM1 Chemical Structure

CAS No. : 1450995-09-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

OHM1 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

查看所有亚型
HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OHM1 is an analog of HIF1α CTAD that inhibits its binding with p300/CBP. OHM1 targets CH1 domain with an affinity of 0.53 μM[1].

体外研究
(In Vitro)

OHM1 (1-20 μM; 24 h) 导致 HIF 启动子活性呈剂量依赖性降低，并在 20 μM 使 MDA-MB-231 细胞在低氧条件下的 HIF1α 转录活性降低至常氧条件下[1].
OHM1 下调缺氧诱导基因表达[1]。
OHM1 (10 μM) 下调了 A549 非小细胞肺癌细胞系中与血管生成、凋亡、细胞增殖和侵袭相关的多个基因，以及几种癌症特异性标记物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OHM1 相关抗体:

RT-PCR[1]

Cell Line: A549
Concentration: 10 μM
Incubation Time: 24 h
Result: Down-regulated the mRNA expression levels of the critical angiogenesis regulator vascular endothelial growth factor (VEGFA) by 80%. Decreased lysyl oxidase (LOX) and glucose transporter 1 (GLUT1) expression.
体内研究
(In Vivo)

OHM1 (15 mg/kg; i.p.; every other day for 15 injections) 降低小鼠 MDA-MB-231 肿瘤体积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice, MDA-MB-231 xenograft model[1]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection, every other day for 15 injections
Result: Reduced the median tumor volume by roughly 50% compared with the untreated group. Did not cause measurable changes in animal body weight or other signs of toxicity in tumor-bearing animals, nor increased the metastasis rate.
分子量

494.63

Formula

C24H42N6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OHM1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OHM11450995-09-1OHM 1OHM-1HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHMDA-MB-231A549BALB/cVEGFALOXGLUT1Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
OHM1
目录号：
HY-124722
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z