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  4. ORC-13661 hydrochloride

ORC-13661 hydrochloride 是一种毛细胞保护剂。ORC-13661 hydrochloride 保护感觉毛细胞免受氨基糖苷类和顺铂 (HY-17394) 的耳毒性。ORC-13661 hydrochloride 是一种可逆的机电传感器 (MET) 通道渗透阻滞剂。

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ORC-13661 hydrochloride Chemical Structure

ORC-13661 hydrochloride Chemical Structure

CAS No. : 1979935-34-6

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ORC-13661 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker[1].

体外研究
(In Vitro)

ORC-13661 (0.10-8.3 μM；野生型 *AB 斑马鱼毛细胞) hydrochloride 保护斑马鱼毛细胞免受多种氨基糖苷类 (AG) 的影响[1]。
ORC-13661 (0.10-20 μM) hydrochloride 保护斑马鱼侧线毛细胞和哺乳动物毛细胞免受 Cisplatin (HY-17394) 影响[1]。
ORC-13661 (0.3 and 3 μM) hydrochloride 是听觉毛细胞 MET 通道的可逆阻断剂。ORC-13661 hydrochloride 阻断 OHC MET 电流。ORC-13661 hydrochloride MET 通道块具有电压依赖性和渗透性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ORC-13661 hydrochloride 相关抗体:
体内研究
(In Vivo)

ORC-13661 (0.2-5 mg/kg; 口服; 每日一次, 持续 10 天) hydrochloride 以剂量依赖性方式保护大鼠的听力免受阿米卡星的影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer 344 rat[1]
Dosage: 0.2, 1, and 5 mg/kg
Administration: Oral administration; daily, for 10 days
Result: Protected hearing in mammals from different AG antibiotics.
分子量

427.35

Formula

C18H20Cl2N4O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ORC-13661 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ORC-136611979935-34-6ORC13661ORC 13661Othersaminoglycosidecisplatinreversibly mechanoelectrical transducerhair cellsInhibitorinhibitorinhibit

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产品名称：
ORC-13661 hydrochloride
目录号：
HY-129677
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