2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. OX-201

OX-201 是 OX2R 的选择性激动剂，EC50 为 8 nM。神经元产生的病理性蛋白质，会以神经活动依赖的方式释放到间质液 (ISF) 中，再通过淋巴通路从??大脑中清除。病理性蛋白质向 ISF 的流出过程与神经元的觉醒状态有关。OX-201 可诱导神经元觉醒并促进 tau 释放到海马 ISF 中。虽然 OX-201 不会改变海马 tau 水平，但对于睡眠/觉醒节律失调的阿尔茨海默病 (AD) 有潜在应用。

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OX-201 Chemical Structure

OX-201 Chemical Structure

CAS No. : 2460722-03-4

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OX-201 相关抗体

Top Publications Citing Use of Products

查看 Orexin Receptor (OX Receptor) 亚型特异性产品:

查看所有亚型
OX2 Receptor OX1 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OX-201 is a selective agonist for OX2R with an EC50 of 8 nM. Pathological proteins produced by neurons are released into the interstitial fluid (ISF) in a manner dependent on neuronal activity and are cleared from the brain via lymphatic pathways. The outflow of pathological proteins to the ISF is related to the arousal state of neurons. OX-201 can induce neuronal awakening and promote the release of tau into the hippocampal ISF. Although OX-201 does not alter hippocampal tau levels, it has potential applications for Alzheimer's disease (AD) associated with sleep/wake rhythm disturbances[1].

IC50 & Target

OX2 Receptor

8 nM (EC50)

OX1 Receptor

8.1 μM (EC50)

分子量

506.49

Formula

C22H23F5N2O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OX-201 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OX-2012460722-03-4OX201OX 201Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorC57BL/6J mouseselectiveADAlzheimer’s Diseasewake-promotingInhibitorinhibitorinhibit

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