Orexin Receptor (OX Receptor) Inhibitors

OX₂ Receptor

OX₁ Receptor

OX₂ Receptor

OX₁ Receptor

OX1

OX₂ Receptor

OX₁ Receptor

OX₂ Receptor, EC₅₀: 8 nM

OX₁ Receptor, EC₅₀: 8.1 μM

human OX2R, Kd: 0.17 nM

human OX1R, Kd: 1.3 nM

OX₂ Receptor, EC₅₀: 0.028 μM

OX₁ Receptor, EC₅₀: 2.75 μM

OX₂ Receptor

OX₂ Receptor

human OX2R, pKi: 8.0
rat OX2R, pKi: 8.1

OX₂ Receptor, IC₅₀: 531 nM
OX₂ Receptor, Ki: 129 nM

OX₁ Receptor, IC₅₀: 3.76 nM
OX₁ Receptor, Ki: 1.1 nM

OX₂ Receptor, IC₅₀: 18 nM
OX₂ Receptor, Ki: 0.5 nM

OX₁ Receptor, IC₅₀: 1789 nM
OX₁ Receptor, Ki: 1584 nM

OX₂ Receptor

OX₂ Receptor

OX2, EC₅₀: 187 nM

OX1, EC₅₀: 8.29 nM

OX2, EC₅₀: 24 nM

OX1, EC₅₀: 24 nM

OX2, :

OX₁ Receptor

human OX2R, pKi: 8.0
rat OX2R, pKi: 8.1

human OX2R, Kd: 0.17 nM

human OX1R, Kd: 1.3 nM

OX₂ Receptor

OX₂ Receptor, Ki: 0.2 nM

OX₁ Receptor, Ki: 3 nM

OX₂ Receptor

OX₁ Receptor, Ki: 57 nM (in whole cell )
OX₁ Receptor, Ki: 27 nM (in cell membrane)

OX2

OX1

OX2, IC₅₀: 417 nM

OX1, IC₅₀: 6 nM

OX2, EC₅₀: 0.13 nM

OX1, EC₅₀: 52 nM

OX₂ Receptor

OX₁ Receptor, Ki: 57 nM (in whole cell )
OX₁ Receptor, Ki: 27 nM (in cell membrane)

OX2, IC₅₀: >10 μM

OX1, IC₅₀: 8 nM

OX2, EC₅₀: 0.13

OX1, EC₅₀: 52

OX₂ Receptor, EC₅₀: <100 nM

human OX2R, Ki: 700 nM

OX₁ Receptor, EC₅₀: 85 ng/mL
human OX1R, Ki: 16 nM

OX₂ Receptor

human OX1R

OX₂ Receptor, EC₅₀: 339 nM

OX2, EC₅₀: 187 nM

OX1, EC₅₀: 8.29 nM

OX₂ Receptor

OX₂ Receptor, IC₅₀: 4.27 nM

OX₁ Receptor, IC₅₀: 295 nM

OX₂ Receptor