Orexin A (human, rat, mouse) (TFA)  (Synonyms: Hypocretin-1 (human, rat, mouse) (TFA))

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats^[1][2][3].

Orexin A (human, rat, mouse) 对 OX1R 和 OX2R 具有高亲和力，在 [Ca^2﹢]i 瞬时测定中其 IC₅₀ 值为 38 nM，EC₅₀ 值为 34 nM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Orexin A (human, rat, mouse) TFA (3-30 mg/kg；iv；5 分钟预测试) 显著增加 10 和 30 mg/kg iv 反应的潜伏期，当从 24.8± 进行 5 分钟预测试时载体处理的小鼠中的 2.0 秒分别为 35.0±3.7 秒和 45.7±4.5 秒^[2]。
Orexin A (human, rat, mouse) TFA (3、10 和 30 mg/kg；iv) 在苯对醌 (PPQ) 之前立即给药，并且在 10 mg/kg 和 594.5± 5.5 秒，30 mg/kg^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

3561.10 (free base)

C₁₅₂H₂₄₃N₄₇O₄₄S₄.xC₂HF₃O₂

固体

White to off-white

{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85.  [Content Brief]

  [2]. Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 2001 May;92(1-2):81-90.  [Content Brief]

  [3]. Kaminski T, et al. Expression of orexin receptors in the pituitary. Vitam Horm. 2012;89:61-73.  [Content Brief]