2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Orexin A (human, rat, mouse) (acetate)

Orexin A (human, rat, mouse) (acetate)  (Synonyms: Hypocretin-1 (human, rat, mouse) (acetate))

目录号: HY-106224B 纯度: 99.93%
COA 产品使用指南

摩尔计算器

Orexin A (Hypocretin-1) (human, rat, mouse) acetate 是一种具有镇痛特性的下丘脑神经肽 (可透过血脑屏障)。Orexin A (human, rat, mouse) acetate 结合并激活两种 G 蛋白偶联受体，即 Orexin-1 受体 (OX1R) 和 Orexin-2 受体 (OX2R)。Orexin A (human, rat, mouse) acetate 可用于食欲调节、神经退行性疾病，以及调节伤害性信息传递的研究。

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Orexin A (human, rat, mouse) (acetate) Chemical Structure

Orexin A (human, rat, mouse) (acetate) Chemical Structure

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1 mg ￥1445
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5 mg ￥3180
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10 mg ￥5100
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Other Forms of Orexin A (human, rat, mouse) (acetate):

Orexin A (human, rat, mouse) (acetate) 相关抗体

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查看 Orexin Receptor (OX Receptor) 亚型特异性产品:

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OX2 Receptor OX1 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Orexin A (Hypocretin-1) (human, rat, mouse) acetate is a hypothalamic neuropeptide with analgesic properties (crosses the blood-brain barrier). Orexin A (human, rat, mouse) acetate binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) acetate can be used in studies of appetite regulation, neurodegenerative diseases and modulation of injurious messaging[1][2][3][4].

IC50 & Target

OX1 Receptor

 

OX2 Receptor

 

体外研究
(In Vitro)

Orexin A (human, rat, mouse) acetate (0.1, 1, 10, 100 nM; 24 h) increases the expression of BDNF in SH-SY5Y human dopaminergic neuroblastoma cells in a dose-dependent manner[1].
Orexin A (human, rat, mouse) acetate (1 nM; 1, 3, 6, 12, 24 h) increases the expression of BDNF, TH, and PI3K in a time-dependent manner in SH-SY5Y cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Orexin A (human, rat, mouse) (acetate) 相关抗体:

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 0.1, 1, 10, 100 nM
Incubation Time: 24 h
Result: Increased the expression of PI3K and TH in a dose-dependent manner.
Significantly induced BDNF expression at the dose of 1 and 10 nM.

Western Blot Analysis[1]

Cell Line: SH-SY5Y cells
Concentration: 1 nM
Incubation Time: 1, 3, 6, 12, 24 h
Result: Showed the expression of PI3K rapidly increased by 72.6 % as soon as 3 h, which maintained at high levels in the following 24 h.
Increased the protein level of BDNF and the increased rate was 44.8%, and the protein level of TH significantly increased at 12 h by 48.5%.
体内研究
(In Vivo)

Orexin A (human, rat, mouse) acetate (300 ng/mouse; i.c.v.; single daily for 8 days) attenuates the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (TH) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevents the depletion of dopamine and its metabolites in the striatum[1].
Orexin A (human, rat, mouse) acetate (10, 30 mg/kg; i.v.; single) shows to be analgesic in the carrageenan-induced thermal hyperalgesia model and PPQ-induced mouse abdominal constriction model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (10-week-old; 22-26 g; MPTP-Induced Mouse Model of PD)[1].
Dosage: 300 ng/mouse
Administration: Intracerebroventricular injection; single daily for 8 days
Result: Reversed MPTP-induced motor impairments via OX1R and increased the protein expression of BDNF in nigral dopaminergic neurons.
Improved MPTP-induced impairments in spatial Learning and memory and protected dopaminergic neurons against MPTP-induced neurotoxicity.
Attenuated the reduction of dopaminergic neurons in the substantia nigra and restored the reduction of dopaminergic fibers in the striatum.
Animal Model: Female ICR mice (17-28 g; carrageenan-induced thermal hyperalgesia model)[2].
Dosage: 10, 30 mg/kg
Administration: Intravenous injection; single; 5 min pre-test
Result: Increased paw withdrawal latency to the thermal stimulus back to baseline levels.
Animal Model: Male ICR mice (17-20 g; phenyl-p-quinone (PPQ)-induced mouse abdominal constriction model)[2].
Dosage: 3, 10, 30 mg/kg
Administration: Intravenous injection; single; given immediately before PPQ
Result: Increased the latency to the first PPQ-induced constriction from 357.4 s (blank control group) to 500.3 s at 10 mg/kg and 594.5 s at 30 mg/kg.
分子量

3561.10 (free base)

Formula

C152H243N47O44S4.xC2H4O2
性状

固体

颜色

White to off-white

Sequence Shortening

{Glp}-PLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 (Disulfide bridge: Cys6-Cys12, Cys7-Cys14)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 50 mg/mL

* "≥" means soluble, but saturation unknown.

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.93%

COA (286 KB) LCMS (91 KB) 元素分析报告 (209 KB)

产品使用指南 (1538 KB)
参考文献

Orexin A (human, rat, mouse) (acetate) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orexin A (human, rat, mouse) (acetate)Hypocretin-1 (human, rat, mouse) (acetate)Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT ReceptorPDparkinson’ s diseaseSH-SY5YanalgesicBDNFTHPI3KPKCInhibitorinhibitorinhibit

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