2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. Orexin Receptor (OX Receptor) Apoptosis
  4. Hypocretin (70-98), human

Hypocretin (70-98), human 是一种多肽，能够与食欲素受体 OX1R 结合，促进凋亡 (apoptosis)。

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Hypocretin (70-98), human Chemical Structure

Hypocretin (70-98), human Chemical Structure

CAS No. : 1129545-33-0

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Hypocretin (70-98), human 相关抗体

Top Publications Citing Use of Products

查看 Orexin Receptor (OX Receptor) 亚型特异性产品:

查看所有亚型
OX2 Receptor OX1 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis[1].

IC50 & Target[1]

human OX1R

 

体外研究
(In Vitro)

Hypocretin (70-98), human 促进表达食欲素受体的细胞凋亡。 OX1R 促进癌细胞凋亡的机制与 Gq 介导的磷脂酶 C 激活和细胞钙瞬变无关。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hypocretin (70-98), human 相关抗体:
分子量

2957.37

Formula

C125H214N44O37S
CAS 号
Sequence Shortening

RSGPPGLQGRLQRLLQASGNHAAGILTMG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
细胞实验： 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Hypocretin (70-98), human 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hypocretin (70-98), human1129545-33-0Orexin Receptor (OX Receptor)ApoptosisHypocretin ReceptorHCRT ReceptorOX1Ranti-cancerInhibitorinhibitorinhibit

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