1. Membrane Transporter/Ion Channel
  2. P2X Receptor
  3. P2X4 antagonist-2

P2X4 antagonist-2 是 P2X4 的拮抗剂,IC50 为 24 nM。

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P2X4 antagonist-2 Chemical Structure

P2X4 antagonist-2 Chemical Structure

CAS No. : 2055601-24-4

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

P2X4 antagonist-2 is an antagonist for P2X4 with an IC50 of 24 nM[1].

IC50 & Target

P2X4 Receptor

24 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
24 nM
Compound: 21
Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins and measured every 2 secs for 120 secs by Fluo8-AM staining based FLIPR assay
Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins and measured every 2 secs for 120 secs by Fluo8-AM staining based FLIPR assay
[PMID: 31746599]
分子量

484.88

Formula

C21H16ClF3N2O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
P2X4 antagonist-2
目录号:
HY-160677
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