2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Palmitoleoyl 3-carbacyclic phosphatidic acid

Palmitoleoyl 3-carbacyclic phosphatidic acid 

目录号: HY-134954
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摩尔计算器

Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) 是一种中等有效的 autotaxin (ATX) 抑制剂，其IC50为 620 nM。 Palmitoleoyl 3-carbacyclic phosphatidic acid 可用于黑色素瘤研究。

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Palmitoleoyl 3-carbacyclic phosphatidic acid Chemical Structure

Palmitoleoyl 3-carbacyclic phosphatidic acid Chemical Structure

CAS No. : 910228-13-6

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Palmitoleoyl 3-carbacyclic phosphatidic acid 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) is an intermediately potent inhibitor of autotaxin (ATX) with an IC50 of 620 nM. Palmitoleoyl 3-carbacyclic phosphatidic acid can be used for melanoma research[1].

IC50 & Target

IC50: 620 nM (Autotaxin) [1]
体外研究
(In Vitro)

Palmitoleoyl 3-carbacyclic phosphatidic acid (3 μM, 22 h) 显著降低 (81%) ATX 和 LPC 诱导的 A2058 细胞侵袭[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Palmitoleoyl 3-carbacyclic phosphatidic acid 相关抗体:
体内研究
(In Vivo)

Palmitoleoyl 3-carbacyclic phosphatidic acid (250 μg/kg, 腹腔注射, 在每只小鼠静脉注射 5×105 个 B16F10 黑色素瘤细胞的 15 min 和 48 h 后注射) 与对照 (57±14 个肿瘤) 相比，阻断了 1/3 的黑色素瘤细胞肺转移 (37±10个肿瘤) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

388.48

Formula

C20H37O5P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Palmitoleoyl 3-carbacyclic phosphatidic acid 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Palmitoleoyl 3-carbacyclic phosphatidic acid910228-13-6Phosphodiesterase (PDE)autotaxininhibitormelanomaLPCA2058B16F10Inhibitorinhibit

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