2. Neuronal Signaling Autophagy
  3. PINK1/Parkin Mitophagy
  4. PARL-IN-1

PARL-IN-1 是一种有效的 PARL 抑制剂，IC50 值为 28 nM。PARL-IN-1 抑制 PARL 并导致 PINK1/Parkin 通路的强烈激活。PARL-IN-1 促进 PINK1/Parkin 依赖性线粒体自噬。

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PARL-IN-1 Chemical Structure

PARL-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Other Forms of PARL-IN-1:

PARL-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PARL-IN-1 is a potent PARL inhibitor with an IC50 value of 28 nM. PARL-IN-1 inhibits PARL and leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-1 promotes PINK1/Parkin-dependent mitophagy[1].

IC50 & Target

IC50: 28 nM (PARL)[1]
体外研究
(In Vitro)

PARL-IN-1 (compound 5; 5 nM-20 μM) impedes mitochondrial stress-induced cleavage of PGAM by PARL in cells and inhibits the cleavage of overexpressed human PGAM5 in HEK293T cells in a dose-dependent manner[1].
PARL-IN-1 (0.1-30 μM; 8 h; HEK293T cells) stabilizes PINK1 and triggers its alternative cleavage and trafficking in living cells[1].
PARL-IN-1 (5 μM; 22 h; HEK293 T-REx cells) blocks the respiratory chain leading to aberrant reactive oxygen species (ROS) production, activates the PINK1/Parkin pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PARL-IN-1 相关抗体:

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 0.1, 0.3, 1, 3, 10, and 30 μM
Incubation Time: 8 hours
Result: Inhibitd the PARL-cleavage of overexpressed PINK1 in a dose-dependent manner.
分子量

720.90

Formula

C39H56N6O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PARL-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARL-IN-1PINK1/ParkinMitophagyMitochondrial AutophagyPINK1ParkinmitophagymitochondriaHEK293T cellsInhibitorinhibitorinhibit

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