2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. PBI-6DNJ

PBI-6DNJ 是一种口服有效的多价糖苷酶 (glycosidase) 抑制剂。PBI-6DNJ 对来自小鼠的 α- 葡萄糖苷酶 (α-glucosidase) 具有良好的抑制活性，Ki 为 0.14 μM。PBI-6DNJ 具有良好的降糖活性。PBI-6DNJ 可用于 2 型糖尿病研究。

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PBI-6DNJ Chemical Structure

PBI-6DNJ Chemical Structure

CAS No. : 2857098-72-5

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PBI-6DNJ 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against α-glucosidase from mice, with a Ki of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research[1].

IC50 & Target

Ki: 0.02 ± 0.002 μM (α-glucosidase from rice), 0.08 ± 0.03 μM (α-mannosidase from jack bean), 0.14 ± 0.007 μM (α-glucosidase from mice), 18.88 ± 0.30 μM (α-glucosidase from aspergilcus niger)[1]
体内研究
(In Vivo)

PBI-6DNJ (0-2 mg/kg, Orally, once) reduces postprandial blood glucose (PBG) levels[1].
PBI-6DNJ (2.0 mg/kg, Orally, daily for 7 day) has good biocompatibility and no damage to mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)[1]
Dosage: 0.5, 1.0 and 2.0 mg/kg
Administration: Orally, once
Result: Reduced postprandial blood glucose (PBG) level, resulting in 24.41 ± 3.02%, 34.65 ± 9.66%, and 37.77 ± 4.35% of decreases in PBG levels at the doses of 0.5, 1.0 and 2.0 mg/kg, respectively.
Animal Model: C57BL-6J mice (twenty-eight, 4-5 weeks old, 18-20 g)[1]
Dosage: 2.0 mg/kg
Administration: Orally, daily for 7 day
Result: Resulted in increase of the level of UREA (8.63 ± 0.59 mmol/L) and decrease of the level of UA level (242.06 ± 14.77 μmol/L). No obvious differences in the levels of UREA and UA were observed. Showed a slight decrease of 0.30 mmol/L in the level of LDL. The AST level of PBI-6DNJ group (269.71 ± 39.77 U/L) was higher than that of the control group (221.38 ± 23.03 U/L), and the ALT level (59.14 ± 7.13 U/L) was lower than that of the control group (70.49 ± 8.78U/L).
分子量

2528.60

Formula

C120H146N26O36
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PBI-6DNJ 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBI-6DNJ2857098-72-5GlucosidaseIminosugarGlucosidase inhibitorMultivalentHypoglycemic effectPerylenetype 2 diabetesInhibitorinhibitorinhibit

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