2. Metabolic Enzyme/Protease
  3. PCSK9
  4. PCSK9-IN-30

PCSK9-IN-30 (Compound 3f) 是一种 PCSK9 抑制剂。PCSK9-IN-30 通过与 PCSK9 的隐性结合槽相互作用，抑制PCSK9 与低密度脂蛋白受体 (LDLR) 的结合 (IC50 为 537 nM)，恢复肝细胞对低密度脂蛋白 (LDL) 的摄取，并最终降低血浆胆固醇水平。PCSK9-IN-30 在小鼠体内表现出良好的生物利用度，可用于心血管疾病领域研究。

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PCSK9-IN-30 Chemical Structure

PCSK9-IN-30 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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PCSK9-IN-30 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PCSK9-IN-30 (Compound 3f) is a PCSK9 inhibitor. PCSK9-IN-30 interacts with a cryptic binding groove of PCSK9, inhibiting the binding of PCSK9 to the low-density lipoprotein receptor (LDLR) (IC50 = 537 nM), restoring the uptake of low-density lipoprotein (LDL) by liver cells, and ultimately reducing plasma cholesterol levels. PCSK9-IN-30 exhibits good bioavailability in mice and can be used for research in the field of cardiovascular diseases[1].

分子量

495.62

Formula

C30H33N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PCSK9-IN-30 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCSK9-IN-30PCSK9Proprotein convertase subtilisin/kexin type 9Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-161940
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