2. Metabolic Enzyme/Protease
  3. PCSK9
  4. PCSK9 modulator-2

PCSK9 modulator-2 (Compound 1) 是一种有效的 PCSK9 调节剂，EC50 值为 202 nM。PCSK9 是最近验证的降低低密度脂蛋白胆固醇 (LDL-C) 的靶点。PCSK9 modulator-2 具有研究高脂血症的潜力。

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PCSK9 modulator-2 Chemical Structure

PCSK9 modulator-2 Chemical Structure

CAS No. : 2365416-53-9

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PCSK9 modulator-2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PCSK9 modulator-2 (Compound 1) is a potent modulator of PCSK9 with an EC50 value of 202 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-2 has the potential for the research of hyperlipidemia[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HepG2 IC50
201.7 nM
Compound: 16
Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISA
Inhibition of human PCSK9 in HepG2 cells incubated for 24 hrs followed by medium replenishment and measured after 24 hrs by ELISA
[PMID: 31227343]
分子量

282.29

Formula

C17H12F2N2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PCSK9 modulator-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCSK9 modulator-22365416-53-9PCSK9Proprotein convertase subtilisin/kexin type 9LDL-ChyperlipidemiaInhibitorinhibitorinhibit

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