2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1-IN-22

PD-1-IN-22 是一种有效的程序性细胞死亡 1 (PD-1)/程序性细胞死亡配体1 (PD-L1) 相互作用的抑制剂，IC50 为 92.3 nM。

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PD-1-IN-22 Chemical Structure

PD-1-IN-22 Chemical Structure

CAS No. : 2349372-98-9

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规格 价格 是否有货 数量
1 mg ￥2207
1 - 2 周
5 mg   询价  
10 mg   询价  

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PD-1-IN-22 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with an IC50 of 92.3 nM[1].

IC50 & Target

IC50: 92.3 nM (programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
92.3 nM
Compound: A22
Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 residues) expressed in HEK293 cells protein-protein interaction after 40 mins by APC-labeled anti-His antibody/
Inhibition of human Fc-tagged PD1 N-terminal domain (Leu25 to Gln167 residues) expressed in HEK293 cells/human His-tagged PDL1 (Phe19 to Arg238 residues) expressed in HEK293 cells protein-protein interaction after 40 mins by APC-labeled anti-His antibody/
[PMID: 32667799]
体外研究
(In Vitro)

PD-1-IN-22 dose-dependently elevates IFN-γ secretion in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1-IN-22 相关抗体:
分子量

459.50

Formula

C25H25N5O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1-IN-22 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1-IN-222349372-98-9PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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产品名称：
PD-1-IN-22
目录号：
HY-128605
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