2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. PD-1/PD-L1-IN-44

PD-1/PD-L1-IN-44 (Compound 22) 选择性的抑制 PD-1/PD-L1 蛋白 (IC50=1.21 nM)。PD-1/PD-L1-IN-44 在动物模型中抑制了肿瘤生长，增强 CD8+ 细胞浸润，且没有毒性。

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PD-1/PD-L1-IN-44 Chemical Structure

PD-1/PD-L1-IN-44 Chemical Structure

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PD-1/PD-L1-IN-44 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD-1/PD-L1-IN-44 (Compound 22) selectively inhibits PD-1/PD-L1 proteins (IC50=1.21 nM). PD-1/PD-L1-IN-44 inhibits tumor growth without toxicity in animal models and increases CD8+ cell infiltration[1].

体外研究
(In Vitro)

PD-1/PD-L1-IN-44 显示出非特异性毒性 (IC50=>20 μM (MDA-MB231), >20 μM (H1299), >20 μM (HCT116), >20 μM (A549))[1]。
PD-1/PD-L1-IN-44 (10 μM; 48 h) 有效抑制 A549/PBMC T 细胞中 A549 细胞的增殖能力，抑制率甚至达到 76.5%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD-1/PD-L1-IN-44 相关抗体:

Immunofluorescence[1]

Cell Line: A549/PBMC T cells
Concentration: 10 μM
Incubation Time: 48 h
Result: Inhibited cell proliferation more than BMS-1 (HY-19991) and BMS-1166 (HY-102011) . Induced PBMC T cells to kill A549 cells
体内研究
(In Vivo)

PD-1/PD-L1-IN-44 (10 mg/kg; i.p.; 每天一次，持续 21 天) 显著抑制了 4T1 模型 小鼠的肿瘤生长[1]。
该药物的溶解制剂为 5% 二甲基亚砜，10% 蓖麻油，85% 生理盐水

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

562.61

Formula

C34H30N2O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD-1/PD-L1-IN-44 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-1/PD-L1-IN-44PD-1/PD-L1PD-1/Programmed death-ligand 1tumourcancerImmunotherapyPharmacophore 4T1 modelInhibitorinhibitorinhibit

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产品名称：
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目录号：
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