PD 119819 

PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis^[1][2].

PD 119819 (5~80 mg/kg; nasogastric intubation) makes monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values is evident after doses of 80 mg/kg^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

438.35

C₂₁H₂₅Cl₂N₃O₃

105277-43-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Macallum GE, et al. Renal and hepatic toxicity of a benzopyran-4-one in the Cynomolgus monkey. Toxicology. 1989;59(1):97-108.  [Content Brief]

  [2]. Jaen JC, et al. Dopamine autoreceptor agonists as potential antipsychotics. 2. (Aminoalkoxy)-4H-1-benzopyran-4-ones. J Med Chem. 1991;34(1):248-256.  [Content Brief]