2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. PD 168568 dihydrochloride

PD 168568 dihydrochloride 是一种口服有效的多巴胺受体 D4 (DRD4) 拮抗剂。PD 168568 dihydrochloride 含有异吲哚啉酮，对 D4 受体相对于 D2 和 D3 具有选择性，其 Ki 值分别为 8.8、1842 和 2682 nM。PD 168568 dihydrochloride 可用于胶质母细胞瘤 (GBM) 研究。

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PD 168568 dihydrochloride Chemical Structure

PD 168568 dihydrochloride Chemical Structure

CAS No. : 1782532-06-2

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规格 价格 是否有货 数量
1 mg ￥649
1 - 2 周
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Other Forms of PD 168568 dihydrochloride:

PD 168568 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Dopamine Receptor 亚型特异性产品:

查看所有亚型
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PD 168568 dihydrochloride is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 dihydrochloride contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 dihydrochloride can be used for glioblastoma (GBM) research[1][2].

IC50 & Target[1]

D4 Receptor

8.8 nM (Ki)

D2 Receptor

1842 nM (Ki)

D3 Receptor

2682 nM (Ki)

体外研究
(In Vitro)

PD 168568 dihydrochloride 对胶质母细胞瘤神经干细胞 (GNS) 表现出选择性抑制，IC50 为 25-50 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PD 168568 dihydrochloride 相关抗体:
体内研究
(In Vivo)

PD 168568 dihydrochloride (3 mg/kg，口服) 可抑制大鼠 amphetamine 刺激的运动活动[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[1]
Dosage: 3 mg/kg
Administration: Oral administration
Result: Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.
分子量

422.39

Formula

C22H29Cl2N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PD 168568 dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 1685681782532-06-2PD168568PD-168568Dopamine ReceptorD4schizophreniadopaminereceptorD2familyInhibitorinhibitorinhibit

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目录号：
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