1. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation
  2. Phosphodiesterase (PDE) TNF Receptor Interleukin Related
  3. PDE4-IN-18

PDE4-IN-18 (compound 1l) 是一种 PDE4 抑制剂 (IC50=1.55 μM),具有抗炎活性。PDE4-IN-18 通过减少过度的免疫细胞浸润和肠膜形成,以及降低滑膜组织中促炎细胞因子 (如 TNF-αIL-6) 的 mRNA 表达来发挥抗炎作用。PDE4-IN-18 可用于类风湿性关节炎和银屑病的研究。

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PDE4-IN-18 Chemical Structure

PDE4-IN-18 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis[1].

IC50 & Target[1]

PDE4

1.55 μM (IC50)

分子量

434.48

Formula

C24H19FN2O3S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PDE4-IN-18
目录号:
HY-162797
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