PEN (human) 

PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83^[1].

Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN^[2].
PEN binds and activates a GPCR in the brain^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

2215.46

C₉₇H₁₅₉N₂₇O₃₂

597578-70-6

固体

White to off-white

AADHDVGSELPPEGVLGALLRV

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.  [Content Brief]

  [2]. Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.  [Content Brief]