2. Apoptosis Immunology/Inflammation
  3. Pyroptosis
  4. Pep19-2.5

Pep19-2.5 是一种合成的抗毒素肽，能够阻断细胞内内毒素信号级联。Pep19-2.5 抑制跨膜和胞质模式识别受体 (PRRs) 介导的脂肽 (LP) 和脂多糖 (LPS) 信号通路。该信号级联与炎症和细胞焦亡 (pyroptosis) 有关。

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Custom Peptide Synthesis

Pep19-2.5 Chemical Structure

Pep19-2.5 Chemical Structure

CAS No. : 1322711-38-5

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规格 价格 是否有货 数量
1 mg ￥600
In-stock
5 mg ￥1600
In-stock
10 mg ￥2600
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Pep19-2.5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs). The signaling cascades lead to inflammation and cell pyroptosis[1].

体内研究
(In Vivo)

Pep19-2.5 (5 mg/kg; i.v.; single dose), combinded with Ceftriaxone (HY-B0712) (15 mg/kg; i.v.; single dose) displays synergism effect and kills bacteria and eliminates bacteremia 30 min post treatment, Pep19-2.5 also notably counteracts the endotoxin-inducing potential of ceftriaxone in sepsis model of rabbit[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sepsis model in male New Zealand rabbits (2-2.5 kg)[2]
Dosage: 5 mg/kg, combinded with 15 mg/kg Ceftriaxone; total volume of 2 mL
Administration: Intravenous injection; extracted blood from the marginal ear vein at different time points post challenge (0, 2, 30, 90 and 180 min)
Result: Killed bacteria and eliminates bacteremia 30 min post challenge;
Inhibited Toll-like receptor 4 agonists in serum 90 min post challenge;
Reduced serum levels of pro-inflammatory cytokines (interleukin-6 and tumor necrosis factor α);
And reverted to hypothermia and gives rise to temperature values indistinguishable from basal levels 330 min post challenge.
分子量

2712.23

Formula

C135H187N37O22S
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

GCKKYRRFRWKFKGKFWFWG
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Pep19-2.5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pep19-2.51322711-38-5Pyroptosislipopeptideslipopolysaccharidespattern recognition receptorsPRRsLPSLPinflammationsepsis modelInhibitorinhibitorinhibit

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目录号：
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