2. NF-κB Immunology/Inflammation
  3. NF-κB Nuclear Factor of activated T Cells (NFAT)
  4. Peptide P60

Peptide P60  (Synonyms: FOXP3 inhibitor P60)

目录号: HY-P1684
产品使用指南 技术支持

Peptide P60 是一种 FOXP3 抑制剂。Peptide P60 能够进入细胞，抑制 FOXP3 的核转位，并降低其抑制转录因子 NF-κB 和 NFAT 的能力。Peptide P60 能够抑制小鼠和人类来源的调节性 T 细胞 (Treg) 的免疫抑制活性，并在体外增强效应 T 细胞的刺激。Peptide P60 可诱发一种淋巴增生性自身免疫综合征，其病理表现与报道的缺乏功能性 Foxp3 的斑驳鼠相似。Peptide P60 可以提高癌症和病毒疫苗的免疫原性。

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Custom Peptide Synthesis

Peptide P60 Chemical Structure

Peptide P60 Chemical Structure

CAS No. : 1319725-20-6

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Customer Review

Peptide P60 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Peptide P60 is a FOXP3 inhibitor. Peptide P60 can enter cells, inhibit the nuclear translocation of FOXP3, and diminish its ability to suppress the transcription factors NF-κB and NFAT. Peptide P60 can inhibit the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, and enhance the stimulation of effector T cells in vitro. Peptide P60 can induce a lymphoproliferative autoimmune syndrome with pathological manifestations resembling those reported in scurfy mice lacking functional Foxp3. Peptide P60 can enhance the immunogenicity of cancer and viral vaccines.[1]

分子量

1994.34

Formula

C95H132N24O20S2
CAS 号
Sequence

Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-Ala-Met
Sequence Shortening

RDFQSFRKMWPFFAM
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Peptide P60 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Peptide P601319725-20-6FOXP3 inhibitor P60Peptide P 60Peptide P-60NF-κBNuclear Factor of activated T Cells (NFAT)Nuclear factor-κBNuclear factor-kappaBantitumor immunotherapiesantiviral immunotherapiesscurfy micelymphoproliferative autoimmune syndromeTregInhibitorinhibitorinhibit

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